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Is it necessary to stack Semaglutide or Tirzpatide if you are already using Retatrutide? - Astersteroids.
Semaglutide is a GLP-1 single receptor agonist, Tirzpatide is a GLP-1 and GIP double receptor agonist, and Retatrutide is a GLP-1, GIP and GCG triple receptor agonist. From their mode of action, we would think that there is a progressive relationship between them. If there is a progressive relationship between modes of action, does that mean there is also a progressive relationship between their effectiveness? So, if we are using the triple receptor agonist Retatrutide , is it necessary to stack Semaglutide or Tirzpatide?
In the use of weight loss peptides, many people are stacking these three peptides, and it has been shown that the effect is better after stacking. If Retatrutide is already the best of the three of them, is it necessary to stack it with weight loss peptides that are not as good as it?
Recently, the idea that Retatrutide doesn’t need stacking has gained a lot of support, and the reasons are summarized below.
Do not understand the mode of action of Retatrutide
Retatrutide not simply synthesize to stimulate GLP-1, GIP and GCG receptors, respectively. Reta design to lose weight in a way that is exactly eight times as effective as naturally occurring GIP (Tirzpatide is twice as effective as naturally occurring GIP), while having less effect on GLP-1 receptors than Tirzpatide. Both Semaglutide and Tirzpatide work by getting you to eat less and weigh less. It’s different with Reta, where you can eat normally and then lose weight normally and get better results than with Sema and Tirz. Retatrutide is a non-equilibrium triple receptor agonist by design. Other companies designed balanced triple receptor agonists to lose weight, but eventually stopped the trials. The action of balanced triple receptor agonists is similar to the pattern of stack, so the failure of these drugs illustrates that the effect of simple stack is not obvious.
The idea of controlling calorie intake
People experienced significant appetite suppression when using Semaglutide and Tirzpatide. Controlling calorie intake is the basic operation of weight loss. When you use Retatrutide and you can eat again, you worry about eating too much to lose weight, and you want to control your appetite with Sema or Tirz. Reta actually loses weight by converting fat into glucose, the part of fat that provides the body with energy and can fight hunger, but only if you reach the optimal dose of Reta. The optimal dose of Reta is 9mg, which needs to titrat gradually from 2mg to 9mg over a period of 4 months. Some people expect to see the weight loss effects of Reta soon and therefore do not give Retatrutide enough time to reach the optimal dose.
In pursuit of rapid weight loss
For the above reasons, the best weight loss from Retatrutide comes after 4 months, and people want to stack up when they haven’t seen significant results after 3 months of using Reta. During these months, you may eat more than you do on Sema and Tirz and worry that excessive calorie intake will lead to weight gain, and stack Sema or Tirz can solve this problem. Therefore, make many people will stack.
This part of the theory supports the idea that Retatrutide doesn’t need a stack. What do you think? Do you stack Retatrutide with Semaglutide or Tirzpetide? -
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Experienced sarms users are no longer satisfied with the sarms solo cycle, but explore the sarms stack which can increase muscle to a greater extent. Here’s a sarms stack Rad140 +MK677 +YK11 +Enclo for your information.
Rad140
In this stack, RAD140 is a true Sarm, targeting muscle mass by binding to androgen receptors in skeletal muscle. RAD140 also encourages the body to burn fat, thereby gaining lean muscle.
MK677
MK677 is a ghrelin (GHS) receptor agonist and a growth hormone secretagogue, similar to a growth hormone agonist, that activates the hypothalamic pituitary gland to produce actual growth hormone, which improves metabolic activity, builds muscle mass, controls hunger levels, and lowers cholesterol levels, among other things.
in addition to having an anabolic effect, in this stack, MK677 helps provide appetite during the cycle, enabling the user to consume enough nutrients to provide a material base for muscle growth.
YK11
Yk11 is a selective androgen receptor modulator (sarms), but it is also a myostatin inhibitor. As a myostatin inhibitor, YK11 unlocks myostatin and promotes greater muscle growth. For people with genetic traits that have a low potential to gain muscle mass, yk11 help to break down genetic barriers and promote muscle growth.
In this stack, the YK11’s special mode of action helps users gain muscle mass quickly, even though the sarms RAD140 has put on enough muscle.
Enclo
Enclo stands for Enclomifene citrate, a non-steroidal SERM(Selective estrogen receptor modulator). By antagonizing the estrogen receptor in the pituitary gland, it reduces the negative feedback effect of estrogen on HPGA(hypothalamic-pituitary-gonad axis), thereby increasing the release of LH(luteinizing hormone) and FSH(Follicle-stimulating hormone) and promoting the production of testosterone.
Rad140+MK677+YK11+Enclo
In this stack, RAD140 has a small inhibitory effect, but yk11 has the structure of steroids, which has a large inhibitory effect on endogenous testosterone secretion. Use enclo in cycle helps to maintain testosterone levels during the cycle and avoid low testosterone.
In the sarms stack, the principle of using only one real sarm is generally followed. in this stack, it looks like two sarms are used, the RAD140 And the YK11. In fact, yk11 is not exactly the same mode of action as SArms for structural reasons. So RAD140+YK11 is also a common stack.
Rad140+MK677+YK11+Enclo is for bulking, not cutting. Because Cutting needs to control caloric intake, the increase in appetite provided by MK677 makes it difficult to control calories, and Yk11 also helps to rapidly expand muscles. Use this stack build muscle, need to deal with testosterone suppression issues, blood pressure issues, and add liver protection as appropriate. -
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Androgenic alopecia is a topic of increasing concern. Does the use of exogenous testosterone to boost overall testosterone levels cause androgenic alopecia hair loss?
I did a little poll on that question. Of the 351 male testosterone users, 43 experienced hair loss after using testosterone, and 351 reported no hair loss after using testosterone for more than a year, and some even had thicker hair after using extrinsic testosterone. The proportion of participants with and without hair loss is shown in the figure below.
Relationship between exogenous testosterone and hair loss
The reason why it is believed that exogenous testosterone causes hair loss is because the higher the level of testosterone, the more DHT will be converted, and thus the androgenetic alopecia. This is indeed the theoretical cause of baldness.
People who use exogenous testosterone instead of other steroids usually do so for the purpose of testosterone replacement therapy (TRT). Therefore, the dose of testosterone used is relatively low, about 200-300mg/wee, and the maximum will not exceed 500mg/week. This dose is used to make up for testosterone levels that decline with age or that are low due to hypogonadism. The purpose of using testosterone in these people is to raise the overall testosterone level to the normal level, or at the position of the normal testosterone level. If testosterone did not affect his hair when he was young and his testosterone level was the highest in his life, chances are that it will not affect his hair after increasing his testosterone level.
People with a family history of hair loss are more likely to lose hair. Therefore, if your hair is more sensitive to DHT, you belong to the population prone to hair loss. Before you use testosterone, your testosterone level may not be enough to convert enough DHT to cause hair loss, and when you use exogenous testosterone to convert more DHT, it may cause hair loss.
Why do I not lose hair after using exogenous testosterone?
First of all, genetics plays a big part, and if your genetics are good, you’ll always be able to keep your hair easily.
Estrogen levels have a lot to do with hair health. Elevated levels of testosterone, in turn, lead to elevated levels of estrogen. Proper estrogen contributes to the health of hair and makes hair grow better. But too much estrogen can cause more side effects in men. Testosterone users will use aromatase inhibitors (AI) to lower estrogen levels. If estrogen is reduced to too low a level, it can make hair quality worse and may lead to hair loss.
In addition, stress and emotional problems can also cause hair loss. After the male testosterone level increases, it will enhance self-confidence and improve physical health to a certain extent. Therefore, if you are not prone to hair loss, hair quality can be improved.
For the vast majority of people who use exogenous testosterone, it is done thoughtfully. They no longer want to experience the side effects of low testosterone levels, compared to which hair is less important. They are willing to give up some others for something more important.
It can also be seen from the vote that the proportion of people who lose their hair because of testosterone is about 12%, and most people are well adjusted to testosterone.
You don’t have to give up your hair. Androgenic alopecia is due to DHT. Reducing the production of DHT while using testosterone can prevent hair loss. Of course, if you are prone to hair loss, hair loss should be prevented in time. Finasteride and Minoxidil are widely used to prevent hair loss. -
Test Propionate vs Test Cypionate: Short ester is more beneficial to maintain the function of HPTA - Astersteroids.
When Bodybuilders used testosterone esters to build muscle, they found that long ester Test Cypionate <http://www.astersteroids.com/steroids-powder-testosterone-cypionate-price-dose-250mg-for-bodybuilding-cycle/> had more sexual side effects than short ester Test propionate <https://www.astersteroids.com/for-sale-testosterone-propionate-for-bodybuilding-price-dosage-and-cycle/>, and these side effects mainly showed inhibition of HPTA(natural testosterone levels) and low libido.
The use of exogenous tests can suppress natural testosterone production, but exogenous tests can replace some of the effects of testosterone. Therefore, most of the time, if use an exogenous Test, rather than other forms of androgen, such as Nandrolone and Drostanolone, you will not feel significant symptoms of low testosterone. Extensive user data has shown that people who use test long ester are more likely to experience side effects in terms of sexual function. The possible reasons are as follows:
Shorter esters are closer to natural testosterone
The half-life of naturally secreted testosterone is very short, and the half-life of testosterone after the addition of ester can reach as long as 15 days. Test Propionate half-life is about 4 days, test cypionate half-life is about 12 days.
Bodybuilders use long esters to pursue long-term stable testosterone levels because stable testosterone levels help users better engage in bodybuilding, which benefits muscle mass and strength growth. However, maintaining high testosterone levels in the body will continue to inhibit HPTA and affect HPTA’s response to the hormone.
Most hormones in the body are produced intermittently, including testosterone. Natural testosterone levels in the body are different from time to time, with distinct peaks and troughs. Over-stable testosterone levels are contrary to the naturally secreted testosterone levels and are not conducive to maintaining the function of HPTA.
Advantages of long esters
One reason people don’t like the short ester is that it requires frequent injections and is more cumbersome. In fact, unless it’s TRT, bodybuilders actually never wait a week to Test Cypionate with a second injection. They will choose M/W/F, EOD, or even ED for better results. In fact, short esters, in addition to benefiting HPTA, also help control side effects, including estrogen side effects. So frequent injections aren’t a problem for bodybuilders.
People prefer long esters because of the stable testosterone levels they provide. When using test short ester at a low testosterone level, users who have been at a high testosterone level suddenly drop in testosterone levels, just like people who have been excited for a long time suddenly quiet down, will be a little tired and lost. But why not take a good rest at this time and give your body a time to recover. It is impossible to stay in a high phase without rest, and HPTA is the same.
conclusion
Having said all this, I’m not telling you to switch to test short ester. Long esters (such as Test Cypionate) do provide stable testosterone levels, and long-term stable testosterone levels help build muscle quickly, so if on test long esters, there is no low libido, no high estrogen, etc., you are well adapted and it is suitable for you. If you are experiencing these side effects, consider a short ester, such as Test propionate. -
Why there is no appetite suppression or even weight gain on Semaglutide for weight loss? - Astersteroids.
Semaglutide , a peptide drug approved by the FDA to treat type 2 diabetes and obesity, achieves weight loss by acting on GLP-1 receptors to control appetite. In short, Semaglutide allows you to reduce your food intake without feeling hungry, thus promoting weight loss. If you do not feel appetite suppression after using Semaglutide, you are still gaining weight, what is the reason?
First, Semaglutide doesn’t work for everyone. If you have been using Semaglutide for a long time and the dosage has been increased to the highest level and still has no effect, then there is no need to continue using Semaglutide. If you’ve just started using Semaglutide and haven’t seen results yet, that’s our topic for today.
Many people start Semaglutide treatment after hearing about the weight loss results of Semaglutide from various sources. Once you don’t see results in time, you start to wonder if Semaglutide is useful.
Related to the dose of Semaglutide
The therapeutic dose of Semaglutide is 1.7-2.4mg per week. To reduce side effects and allow the body to adjust to the drug, it is usually titrated from a low dose to a therapeutic dose. In the process of titration, it takes several months to experience, so during this time, the effect of the drug is not obvious.
Some people start with 0.5mg, continue for four weeks, then increase to 0.75mg, and then to 1mg. Others start at 0.25mg, increase to 0.5mg after a month, and then need to increase to 0.75mg after four weeks on 0.5mg, and then 1mg. However, when he was still at 0.5mg and did not see appetite suppression and weight loss, he became suspicious of the effects of Semaglutide.
In fact, when the user is still at 0.5mg, this dose has not reached the therapeutic dose, so the suppression of appetite may not be significant. If you still maintain your previous eating habits and caloric intake, you will gain weight in the past, but now even on Semaglutide, the caloric surplus will still cause weight gain.
Therefore, on Semaglutide, it is necessary to remain patient and wait for the actual dose to reach the therapeutic dose.
Individual related
The actual effect of Semalutide varies from individual to individual, which is also the reason why some people cannot achieve weight loss by using Semaglutide. Some people feel the effects and start to lose weight when they start using Semaglutide, while others need to reach a therapeutic dose to lose weight. Our bodies are complex, and many drugs take time to show their effects.
If you have increased your dose to a therapeutic dose and are still not losing weight, it is time to consider whether Semaglutide will work for you.
Develop good eating habits in semaglutide for weight loss
Many people who are severely obese are unable to control their desire to eat. Semaglutide makes it easier for users to fill up and lose the desire to overeat, thereby starving them to their target weight. This also shows that the basic weight loss is to reduce the intake of calories.
The common thinking of Semaglutide users is: because I can’t control my desire to eat more, use semaglutide to help control the appetite, and if the appetite is not best controlled on Semaglutide, then Semaglutide is not working well.
While using Semaglutide, we can rely on it to some extent to control our food intake, but it is still important to develop healthy eating habits. If you stop using Semaglutide after you have successfully lost your goal weight, it is still possible to regain the weight if you still eat excessive calories and do not exercise. Good eating habits can help you keep the weight off without gaining it back after you’ve lost it.
Therefore, in the process of losing weight, you should be patient and pay attention to the cultivation of habits. -
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YK11? is a compound with the characteristics of both sarms and steroids, Some people think it is better to stack use, others think it is better to use alone. What is the situation?
Effect of YK11
YK11 is a myostatin inhibitor that breaks down genetic restrictions on the body and allows people who cannot grow muscle to achieve muscle growth. So, it’s effective for people with genetic traits that have low potential to gain muscle mass. Because some people are naturally high in myostatin, it can be difficult to gain muscle mass. YK11 acts as an inhibitor of myostatin, and even if bodybuilder does not have the right genetic structure, it can grow muscle and improve muscle performance with the help of YK11.
At the same time, it is an androgen receptor modulator that binds to AR in skeletal muscle through the same mode of action as sarms to achieve the purpose of muscle growth.
Therefore, the muscle-building effect of sarms YK11 is not weaker than that of testosterone, and at the same time, as sarms, it has less inhibitory effect on the body than AAS. If yk11 is used alone, there is great muscle mass gain.
YK11 stack
Because yk11 has the structure of steroids, its suppression is much higher than some other sarms. In order to avoid the possible effects of a decrease in naturally secreted testosterone levels due to suppression during yk11 use, some bodybuilders prefer to add testosterone to the yk11 cycle. This is equivalent to using the YK11 stack.
One reason bodybuilders choose sarms is that they have less suppression of natural testosterone levels and thus fewer side effects. If the use of yk11 also requires stack testosterone, it further suppresses natural testosterone levels. If you forgo yk11 in favor of rad140 or lgd4033 cycle, you can also gain a significant amount of muscle mass with less inhibition. Therefore, many people will choose the safer sarms cycle instead of the yk11 cycle.
And yk11’s muscle-beneficial effects have attracted more bodybuilders to use it, even when stacked with testosterone. Because YK11’s mode of action is not exactly the same as sarms, it is also a partial agonist of the androgen receptor and can be stacked with other sarms for better effects. Both yk11 cycle and yk11 stack cycle ultimately require PCT to restore testosterone levels, so using yk11 stack cycle is more cost-effective.
Although yk11 has a large suppression effect, it still has fewer side effects than steroids. It is androgenic, but does not cause problems like prostate problems and androgenic alopecia like testosterone does. -
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Forums are full of people discussing the side effects of testosterone injections, why are so many people still using testosterone, and are they worth it?
Why do so many people discuss the side effects of testosterone injections on forums? This is because so many people are getting testosterone injections. Except for those who are well tolerated, have no side effects, or have all side effects resolved by the doctor, the base of people who come to the forum because the problem is not resolved is still that large. The fact that more and more people are talking about it indicates that the range of testosterone users is expanding.
We can see that in the process of using testosterone, many people talk about having to check their blood pressure regularly, quit smoking, control drinking, adhere to injections (may be lifelong injections, but also need to spend more money), and even need to take some additional drugs, such as liver protection, anti-estrogen and so on. That sounds like a complicated thing to do. Are the benefits of using testosterone worth all the things we do?
Except for the few who quit because of problems they couldn’t solve, most of them are sticking with it. So, the results are clear: worth it, especially for those with low testosterone levels.
When you are too tired to function every afternoon; When you want to participate in some outdoor activities, but are discouraged halfway up the mountain; When you lose muscle mass with age and your belly gets bigger… These little problems can knock your confidence and affect the quality of your life. However, problems such as fatigue, decreased self-confidence, decreased libido, muscle loss, and osteoporosis can all be solved by testosterone.
Will there are side effects of using testosterone?
Of course there will be. But every side effect has a solution, you just need to check regularly and follow your doctor’s advice.
Afraid of injections? Oral testosterone has even been developed to solve the injection problem. Worried about pain from intramuscular injections? Subcutaneous injections have also been found to be a good solution.
Long-term testosterone injections cost money? Compared to the libido, muscle mass, less effort, better fitness results, more extroversion, more confidence, more energy, spontaneous erections on demand, etc., increased testosterone levels are worth the cost (money). At the same time, isn’t making money for a better life?
Of course, before deciding to use testosterone, you should do a blood test, fully listen to the doctor’s advice, and do not start blindly, lest you will end more blindly. -
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For bodybuilders, we’ve talked a lot about how to boost your testosterone levels, such as exercising, Enclomiphene, or extrinsic testosterone. In talking about these topics, we are assuming that you are building muscle for the purpose of bodybuilder, today we are talking about normal conditions to increase testosterone levels.
Testosterone levels are important for bodybuilders, and equally important for every man. Testosterone makes men men. When we say someone has higher testosterone than others, it’s like saying they’re more masculine than others. How to increase testosterone levels is crucial for every man.
Maintain a healthy lifestyle
A healthy lifestyle helps boost testosterone levels. This includes eating a healthy diet, maintaining a balanced diet with protein and minerals and healthy fats, and eating less processed foods. In addition to eating a healthy diet, avoid smoking and excessive alcohol consumption, which would lower testosterone levels and also carry a number of health risks.
Maintain a healthy weight
Obese men have low testosterone levels that have been proven by studies, while overly thin men seem to have low testosterone levels. Therefore, maintaining a healthy weight will make you look like you have higher testosterone levels, which is actually the case. Regular exercise helps maintain healthy weight gain and increases testosterone levels. Getting enough sleep and managing your own stress can also help boost your testosterone levels and lead to a healthier body.
Avoid exposure to chemicals
With the development of agriculture and industry, the number of people with infertility and infertility is increasing, which is link to some chemicals present in pesticides and personal care products, which can interfere with hormone balance and affect male testosterone levels and fertility.
Consider natural supplements
Proper supplementation of vitamin D and zinc both help with testosterone production, but medical advice should be followed and may have the opposite effect if taken in excess.
Consider TRT
If your testosterone level is already very low and is beginning to affect your normal life, and natural ways have not been able to increase testosterone levels, you can consider TRT(testosterone replacement therapy).TRT is the use of external testosterone? <http://www.astersteroids.com/testosterone-base-injection-for-sell-muscle-building-dosage-cycle-and-half-life/>to replace the role of your own testosterone, so as to treat the problem of insufficient endogenous testosterone levels. -
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In the use of bodybuilding supplements, the most direct impact on the body is the inhibition of their own testosterone level, is there a growth of muscle mass without affecting their own testosterone levels of supplements?
AAS
AAS is an exogenous androgen. The use of exogenous androgen in the bodybuilding cycle will definitely affect the secretion of testosterone. During this process, the level of testosterone in the body may still in homeostasis, but this balance is not controll by HPTA(hypothalamic-pituitary-testicular axis), but the secretion of endogenous testosterone gradually decreases, and AAS supplements this part of testosterone and balances the levels of testosterone in the body at a higher level.
Sarms
SARMs are not androgens, and the use of sarms in the bodybuilding cycle theoretically does not affect endogenous testosterone levels. However, this is not the case. sarms work by binding to androgen receptors, and by taking up a portion of the androgen receptors, the body produces an extra portion of testosterone. The brain detects that there is more testosterone secreted and reduces testosterone production. Therefore, if you use sarms, you will still reduce some of your own testosterone levels.
How can I maintain a stable testosterone level while using AAS and sarms
Since both AAS and SARMS use reduce endogenous testosterone levels, is it possible to maintain normal testosterone levels in the process? It is possible to use these supplements to stack testosterone to replenish the testosterone that less produced. But in doing so, it still suppress the testosterone level.
So bodybuilders began experimenting with the use of gonadotropins in the cycle, which unblocks the inhibition of HPTA by high testosterone levels so that testosterone is release continuously . Enclomiphene is commonly to maintain the level of endogenous testosterone.
Are there supplements that don’t affect testosterone level at all?
In addition to natural additives and strengthening exercises, only a few that are classified as sarms are other receptor agonists (which do not act on androgen receptors) that do not affect testosterone levels. gw501516 <>, for example, helps build muscle by regulating metabolism to boost energy levels and endurance. However, these supplements are not as effective as sarms and AAS in building muscle. -
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Testosterone and AAS injections are intramuscular injection (IM) and subcutaneous injection (SubQ), which of these two injection methods is better?
IM vs SubQ basic info.
§ IM refers to the injection of AAS into the muscle and SubQ refers to the injection of AAS into the subcutaneous tissue.
§ IM injection is shallow and SubQ injection is deeper. As a result, IM injections requires longer needles.
§ IM inject at a 90-degree Angle, while SubQ inject at a 45-90 degree Angle.
§ The injection site of IM is mainly Thigh(Quads), Delts, Hip and Gluteus. SubQ inject in areas with fatty tissue, such as the abdomen and upper buttocks.
Advantages and disadvantages of IM
Because there are larger and more blood vessels in the muscle than in the subcutaneous tissue, AAS absorb faster when injected into the muscle. Therefore, AAS injection by IM can take effect quickly, and the maximum efficacy peak appears earlier and the peak value is higher. Because of the rapid absorption rate using IM injections, the peak of serum testosterone levels after IM injection of AAS is more predictable. Therefore, after IM injection, it is easier for individuals to determine the time when their own serum testosterone level will peak, and thus easier to control the peak testosterone level.
The disadvantages of IM are also obvious, that is, because the injection is deeper, it is more likely to cause pain, and because there are more blood vessels in the muscle, inexperienced users may stick the needle into the blood vessel.
Due to the depth of IM injection, the subcutaneous tissue and fat are thicker for overweight or obese users, and SubQ may actually do when doing IM, which they may not know.
Advantages and disadvantages of SubQ
Some injection sites suitable for IM are not convenient for personal injection, SubQ injection into the subcutaneous tissue, which is easier to operate. SubQ inject in a shallow location and with a smaller needle size, which is less likely to cause injection pain or problems with blood vessels.
In terms of drug absorption, SubQ is injected under the skin and into the fat, and absorption is slower, so the time to reach the peak concentration of the drug is slower. However,SubQ provides more stable testosterone levels than IM.
For bodybuilders, the goal of injecting AAS is not just to stabilize testosterone levels, but for more muscle mass and strength. The user would think that injecting AAS into the muscle would preferentially bind to the androgen receptors in the muscle, thus achieving the purpose of muscle building.
During the use of AAS, the main source of estrogen is the aromatization of testosterone. In general, there are more aromatases in fat, so user thinks that if AAS is injected into fat, more of it will be aromatized into estrogen.
Natural testosterone production fluctuates, with different testosterone levels at different times of the day. The main difference in the effects of IM and SubQ is that one provides a higher testosterone peak and one provides a more stable testosterone level. You can choose the injection method according to your own purpose. -
How to solve the problem that semaglutide weight loss does not work after the plateau? - Astersteroids.
Weight-loss drugs have a plateau, after which further weight loss is slowed or stopped. What should I do when semaglutide weight loss plateau appears ?
Semaglutide plateau
Semaglutide weight loss As with other weight loss methods, the body will eventually stabilize at an appropriate weight, which may or may not be the user’s goal weight. If you want to continue to lose weight after reaching the weight loss plateau of the drug, or to avoid weight regain, you need to take the drug for life.
Semaglutide is an FDA-approved weight loss drug. It mimics a naturally occurring hormone that provides the brain with a sense of fullness, slows digestion, and allows food already consumed to leave the body more slowly, successfully helping many obese people lose significant amounts of weight. However, after the weight reaches a certain point, the rate of weight loss slows down until it stops.
Semaglutide plateaus after about 60 weeks of continuous use. At this point, the user has usually lost a significant amount of weight and is gradually approaching a healthy weight, and the body is more inclined to retain calories to protect itself.
At the beginning of weight loss, when you reduce your energy intake, your body will meet its energy needs from other sources such as glycogen (including breaking down fat), which will lead to weight loss. Over time, as the weight lost gradually increases, the body compensates by slowing down the metabolism. When your metabolism is equal to the amount of energy you take in from food, you’ve hit a plateau. This is the genetic protection of the body, which also leads to the cessation of weight loss.
How to solve the semaglutide plateau
If you need to cross the plateau and start losing weight again, you need to change the body’s energy balance again. This can be done by changing your diet or increasing physical activity.
Another way to change the plateau is to increase the dose of the drug. The dose of Semaglutide is 1mg to 2.4mg per week, with gradual increases from the lowest dose to the highest dose. However, after reach the maximum dose, we can’t increase the dose, otherwise it will bring more side effects. So increasing the dose of the drug is limite.
The slimming peptide Tirzpatide <https://www.astersteroid.com/tirzepatide-a-new-dual-action-type-ii-diabetes-drug-showed-better-weight-loss-results-than-semaglultide/> and Retatrutide <https://www.astersteroids.com/triple-receptor-agonist-peptides-retatrutide-ly-3437943-benefits-in-weight-loss/> developed successively also indirectly solved the problem of plateau of Semaglutide <https://www.astersteroids.com/type-2-diabetes-treatment-semaglutide-wegovy-fda-approved-for-healthy-weight-loss/>. Semaglutide is a single receptor agonist of GLP-1, Tirzepatide is a double receptor agonist of GIP and GLP-1. Retatrutide is a triple receptor agonist for GIP, GLP-1 and GCG. Thus, there is equivalent to a progressive relationship between the three drugs, and after reaching a plateau with single-receptor agonists, dual-receptor agonists would work.
However, in the actual process of weight loss, if not only rely on weight loss drugs, but can cooperate with physical activities, it will be more healthy weight loss. After reaching the plateau, actively participate in physical activities, even if the weight is no longer loss, but the body composition is changing. Your body will be more symmetrical, your posture will become better, and your health will be greatly improve. -
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For bodybuilders, a high or low level of testosterone is closely related to gaining and maintaining muscle mass and strength, and we generally think that the higher the level of testosterone, the easier it is to build muscle, so what is the maximum level of testosterone our body can effectively use?
Testosterone levels in relation to muscle mass and strength
The older you get, the more difficult it is to build muscle and maintain the muscle mass you’ve gained, mainly because testosterone levels in adult men decline with age. Similarly, men’s strength levels and bone health tend to decline as they age.
It is clear that low levels of testosterone are not conducive to building and maintaining muscle mass and strength, and are not conducive to the health of bones.
500mg/week testosterone dose could raise testosterone to what level?
Normal testosterone levels range from about 10-30 nmol/L, and under special circumstances, some people’s normal testosterone levels will exceed 30 nmol/L. So, with greater testosterone levels, can our bodies use them effectively?
The study showed that on day 14 after the first 500 mg (15.02±0.76 nmol/L) Test T, the participants’ testosterone levels increased by 360%, that is, about 54.07nmol/L (1557ng/dL), which is well above the maximum value of the testosterone range.
500mg/week is the dosage for novice bodybuiders and 1000mg/week for experienced bodybuilders. There is no experimental data on 1000mg/week doses, but if inject 1000mg of testosterone weekly, The maximum testosterone level in the blood is much higher than 1500ng/dL.
Is it necessary to use higher testosterone doses?
Bodybuilders use exogenous testosterone to build muscle by putting their bodies through tough workouts, they work very hard to make these testosterone would be use in building muscle mass and increase strength, Not to make yourself angry, aggressive, or more self-centered. However, they are still not immune to the side effects of high doses of testosterone, so the corresponding side effects need to be addressed in cycle and PCT.
So, if you do not have a reasonable plan, blindly increase their serum testosterone levels, perhaps the final result will not be as you want. -
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For many people, 300ng/dL is a very low testosterone level. If the testosterone level is this value, there may be certain symptoms of low testosterone. However, normal testosterone levels range from 264 to 916ng/dL, indicating that 300ng/dL is a normal value. Why is there such a wide range of testosterone levels?
This is because men’s testosterone <> levels are constantly changing throughout their lives, and this change generally follows the same rule, that is, “with the growth of age, and year by year.” The age of 20 is about the highest level of testosterone in a man’s life, and after that, testosterone levels will decline every year.
Does anyone’s testosterone level rise from year to year?
It is true that there are people whose testosterone level rise with age without the use of exogenous testosterone and other drugs that promote testosterone production. Here is a case study of a 40-year-old man with a blood test result of total T=1082 and Free T=10. According to him, he did not use exogenous testosterone, nor did he use other drugs that would promote testosterone production.
The hypothalamic-pituitary-testicular axis (HPTA) controls the secretion of testosterone. When the body’s testosterone levels are low, HPTA activates positive feedback to start promoting testosterone secretion. When the body’s testosterone level reaches the maximum threshold, HPTA initiates a negative feedback that begins to inhibit the secretion of testosterone, so that the testosterone level is in dynamic equilibrium.
The normal testosterone level is between 264 and 916ng/dL, the maximum 916 is about the testosterone level of a man when he is 20 years old, and the minimum 264 is the testosterone level of an elderly man. What happens if a man reaches the age of 40 and finds that his testosterone level exceeds 1,000 ng/dL? Of course, at first you might be happy, like you’re 20 again. Then, you might worry, is there something wrong?
What’s the problem?
When the testosterone level exceeds the maximum of this age, the first thing to consider is whether there is a problem with HPTA, at this time, the pituitary gland is usually checked, whether the pituitary tumor affects the function of HPTA.
If the test is completed and no physical problems are found, it is also possible to have a testosterone level of 1000ng/dL at the age of 40, and it is said that some young men in the Colombian army test for testosterone levels as high as 1500 ng/dL, which may be related to genetics.
Are there other factors that cause testosterone levels to rise? It is said that this man measured his testosterone level above 1000 after he lost weight. Do you know how much weight he lost? Two hundred pounds. And he’s still on a diet.
Some experiments have shown that fasting increases testosterone levels. At the same time, he has lost a lot a weight and is a new him now. People who are overweight have lower testosterone levels than people of normal size. If a person is severely overweight at a young age, then his testosterone levels are low, and when he loses weight and keeps building muscle, more muscle requires more testosterone levels to maintain, then his testosterone levels will be much higher than if he is obese. At the same time, if he is still on a diet, testosterone levels do rise naturally.
Of course, if there is a sudden natural increase in testosterone levels, it is necessary to seek medical attention in time to rule out the factors of disease. -
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Normal testosterone levels are between 264 and 916ng/dL, while some men with high testosterone level around 1000ng/dL still have low testosterone symptoms, including severe fatigue, slow recovery from exercise, libido problems, mild ED, depression, anxiety, and even reduced erections in the morning. Today we talk about possible causes.
Production and form of testosterone
The hypothalamic-pituitary-testicular axis (HPTA) controls the release of testosterone. After testis release the testosterone , this part of testosterone does not enter the blood circulation directly, but part of it bind to SHBG (sex hormone binding globulin), part of it bind to albumin, and only a small part (about 2%) unbind and can bind freely to androgen receptors. To make a difference. Therefore, this part of the unbound state of testosterone is Free T. The higher the level of Free T, the more benefits of high testosterone levels.
In addition to Free T, a portion of testosterone binds to albumin. Albumin is a carrier protein that has a low binding force with testosterone and can easily separate from the bind testosterone. This testosterone, which binds to albumin, arrive various parts of the body in the blood circulation. And then when testosterone separate from albumin, it also acts as testosterone.
The part of testosterone that binds to SHBG is difficult to separate from SHBG because it has a high affinity with SHBG. Therefore, this part of testosterone is equivalent to being wasted, unable to produce corresponding effects.
Conclusion
So, Free T is the most potent testosterone, followed by albumin bound testosterone, and finally SHBG bound testosterone. When we take a blood test, the total testosterone measured includes the part of the testosterone that is bound to SHBG, so when the total testosterone level is high, it does not mean that the body has a high level of available testosterone.
When you have a high testosterone level and, at the same time, a high SHBG level, then you are still likely to have low testosterone symptoms.
Boron helps reduce SHBG levels. There is also Proviron , a weak anabolic steroid that preferentially binds to SHBG, increasing the level of free testosterone and improving the utilization of testosterone and other AAS. -
Compare Hexarelin Acetate and Ghrelin: Unlocking the secret of stimulating growth hormone secretion - Astersteroids.
GHRH (growth hormone releasing hormone) based on the development of growth hormone secretadotropin, because it is a synthetic form of GHRH or a cut from the amino acid sequence of GHRH, and has a similar role to GHRH in promoting HGH secretion. Hexarelin Acetate , on the other hand, has a different structure than GHRH, but is rather similar to GHRP-6, mimicking the effects of Ghrelin by acting as a Ghrelin receptor agonist. So, what is the relationship between Hexarelin Acetate and Ghrelin, and how do they increase HGH levels?
Hexarelin Acetate: a synthetic peptide
Hexarelin Acetate is a synthetic peptide derived from the growth hormone releasing peptide (GHRP) family. It was originally developed to stimulate the release of growth hormone and promote growth in laboratory animals. The main mechanism of action of Hexarelin involves binding to the auxin receptor, the growth hormone secretagotor (GHS-R1a). By activating this receptor, Hexarelin effectively stimulates the pituitary gland to release more growth hormone into the blood.
Ghrelin: The natural hunger hormone
Ghrelin is a natural peptide hormone that plays an important role in regulating hunger and appetite. It is produced mainly in the stomach and is released when the stomach is empty, signaling the brain to eat. Ghrelin also binds to the GHS-R1a receptor, much like Hexarelin, but its main function is to stimulate the release of growth hormone during fasting or calorie restriction.
Hexarelin Acetate and Ghrelin: growth hormone stimulation
Both Hexarelin Acetate and ghrelin have the unique ability to stimulate the release of growth hormone in the body. This common mechanism of action makes them valuable tools in the fields of research, medicine and exercise science. Increased levels of growth hormone can have a range of benefits, including promoting muscle growth, reducing fat, improving energy, and potentially anti-aging effects.
Key differences between Hexarelin Acetate and Ghrelin: natural and synthetic
The most significant difference between Hexarelin and Ghrelin is their origin. Ghrelin is a naturally occurring hormone, while Hexarelin is a peptide synthesized in the lab. The main role of Ghrelin is to regulate hunger and appetite, while Hexarelin is specifically designed to stimulate GH release. Although the two compounds activate the same GHS-R1a receptor, their effects differ due to the synthetic nature of Hexarelin.
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